首页|前列舒通胶囊联合坦索罗辛治疗轻度良性前列腺增生患者的效果

前列舒通胶囊联合坦索罗辛治疗轻度良性前列腺增生患者的效果

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目的:观察前列舒通胶囊联合坦索罗辛治疗轻度良性前列腺增生(BPH)患者的效果.方法:回顾性分析 2021 年 3 月至2023年3月该院收治的120例轻度BPH患者的临床资料,按照治疗方法不同将其分为对照组和观察组各60例.对照组予以坦索罗辛治疗,观察组在对照组基础上联合前列舒通胶囊治疗,两组均治疗 12 周.比较两组临床疗效,治疗前后排尿功能指标(残余尿量、平均尿流率、最大尿流率)水平、炎性指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、环氧合酶-2(COX-2)]水平、国际前列腺症状评分表(IPSS)评分、国际勃起功能指数-5(IIEF-5)评分,以及不良反应发生率.结果:观察组治疗总有效率为 91.67%(55/60),高于对照组的 76.67%(46/60),差异有统计学意义(P<0.05);治疗后,观察组残余尿量少于对照组,平均尿流率、最大尿流率水平均高于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-6、TNF-α、COX-2 水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组IPSS评分低于对照组,IIEF-5 评分高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:前列舒通胶囊联合坦索罗辛治疗轻度BPH患者可提高治疗总有效率和IIEF-5 评分,改善排尿功能,降低炎性指标水平和IPSS评分,效果优于单纯坦索罗辛治疗.
Effects of Qianlie Shutong capsules combined with Tamsulosin in treatment of patients with mild benign prostatic hyperplasia
Objective:To observe effects of Qianlie Shutong capsules combined with Tamsulosin in treatment of patients with mild benign prostatic hyperplasia(BPH).Methods:The clinical data of 120 patients with mild BPH admitted to this hospital from March 2021 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,60 cases in each group.The control group was treated with Tamsulosin,while the observation group was treated with Qianlie Shutong capsules on the basis of that of the control group.Both groups were treated for 12 weeks.The clinical efficacy,the levels of urinary function indexes(residual urine volume,mean urinary flow rate,maximum urinary flow rate),the inflammatory indexes[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),cyclooxygenase-2(COX-2)]levels,the international prostate symptom score(IPSS),the international index of erectile function-5(IIEF-5)score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.67%(55/60),which was higher than 76.67%(46/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the residual urine volume of the observation group was less than that of the control group,the average urinary flow rate and maximum urinary flow rate were higher than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-α and COX-2 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the IPSS score of the observation group was lower than that of the control group,the IIEF-5 score was higher than that of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Qianlie Shutong capsules combined with Tamsulosin in the treatment of mild BPH patients can improve the total effective rate of treatment and the IIEF-5 scores,improve the urinary function,reduce the inflammatory index levels and the IPSS score.Moreover,it is superior to single Tamsulosin treatment.

TamsulosinQianlie Shutong capsulesBenign prostatic hyperplasiaUrination functionInflammatory reactionAdverse reaction

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商丘市中心医院泌尿外科,河南 商丘 476000

坦索罗辛 前列舒通胶囊 良性前列腺增生 排尿功能 炎症反应 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(5)
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