Effects of Qianlie Shutong capsules combined with Tamsulosin in treatment of patients with mild benign prostatic hyperplasia
Objective:To observe effects of Qianlie Shutong capsules combined with Tamsulosin in treatment of patients with mild benign prostatic hyperplasia(BPH).Methods:The clinical data of 120 patients with mild BPH admitted to this hospital from March 2021 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,60 cases in each group.The control group was treated with Tamsulosin,while the observation group was treated with Qianlie Shutong capsules on the basis of that of the control group.Both groups were treated for 12 weeks.The clinical efficacy,the levels of urinary function indexes(residual urine volume,mean urinary flow rate,maximum urinary flow rate),the inflammatory indexes[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),cyclooxygenase-2(COX-2)]levels,the international prostate symptom score(IPSS),the international index of erectile function-5(IIEF-5)score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.67%(55/60),which was higher than 76.67%(46/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the residual urine volume of the observation group was less than that of the control group,the average urinary flow rate and maximum urinary flow rate were higher than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-α and COX-2 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the IPSS score of the observation group was lower than that of the control group,the IIEF-5 score was higher than that of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Qianlie Shutong capsules combined with Tamsulosin in the treatment of mild BPH patients can improve the total effective rate of treatment and the IIEF-5 scores,improve the urinary function,reduce the inflammatory index levels and the IPSS score.Moreover,it is superior to single Tamsulosin treatment.