Value of serum IL-6,PCT,SAA and NF-кB levels in differential diagnosis of bacterial and viral respiratory tract infections in children
Objective:To investigate value of the levels of serum interleukin-6(IL-6),procalcitonin(PCT),amyloid protein A(SAA)and nuclear factor-κB(NF-κB)in differential diagnosis of bacterial and viral respiratory tract infections in children.Methods:The clinical data of 100 children with respiratory tract infection diagnosed and treated in this hospital from April 2022 to April 2023 were retrospectively analyzed.According to the results of the pathogen examination,the children were divided into bacterial infection group 43 cases and viral infection group 67cases.The baseline data and the serum IL-6,PCT,SAA and NF-кB levels before the treatment were compared between the two groups.Using bacterial infection as positive,the receiver operating characteristic curve(ROC)was drawn to analyze the value of single and combined detection of IL-6,PCT,SAA and NF-кB levels in the differential diagnosis of bacterial and viral respiratory tract infections.Results:There were no significant differences in the baseline data such as gender,age,body mass index,tonsillar and posterior pharyngeal abscess between the two groups(P>0.05).The levels of serum IL-6,PCT and SAA in the bacterial infection group were higher than those in the viral infection group,the level of serum NF-кB was lower than that in the viral infection group,and the differences were statistically significant(P<0.05).The areas under the curve(AUC)of single detection of serum IL-6,PCT,SAA and NF-кB levels in the diagnosis of bacterial respiratory tract infection were all>0.7,which had certain diagnostic value.The AUC of combined detection was 0.970,which was greater than that of single detection of each index,and the diagnostic value was higher.Conclusions:The levels of serum IL-6,PCT,SAA and NF-кB are closely related to the pathogenic types of the children with respiratory tract infection.The application value of combined detection of each index in the identification of bacterial and viral respiratory tract infections is greater than that of single detection.
BacteriaVirusChildrenRespiratory tract infectionInterleukin-6ProcalcitoninAmyloid protein ANuclear factor-κBDifferential diagnosis
万方数据
维普
