Predictive value of blood lactic acid and high mobility group protein B1 for poor prognosis in children with neonatal pneumonia
Objective:To analyze predictive value of blood lactic acid and high mobility group protein B1(HMGB1)for poor prognosis in children with neonatal pneumonia(NP).Methods:A total of 120 children with NP admitted to the hospital from March 2021 to March 2023 were selected as the study subjects and included in the observation group.Another 120 healthy newborns born in this hospital during the same period were selected as the control group.The levels of blood lactic acid and HMGB1 in the two groups were detected.The prognosis of the NP children was judged,the levels of blood lactic acid and HMGB1 in the NP children with different prognosis were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of single and combined detection of blood lactic acid and HMGB1 for poor prognosis in the children with NP.Results:The levels of blood lactic acid and HMGB1 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of blood lactic acid and HMGB1 in the NP children with poor prognosis were higher than those in the NP children with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single blood lactic acid detection,single HMGB1 detection and combined detection for predicting poor prognosis of the NP children were 0.791,0.717 and 0.825,separately,the predictive value of combined detection was higher than that of single detection,and the differences were statistically significant(P<0.05).Conclusions:The predictive value of combined detection of blood lactic acid and HMGB1 for poor prognosis in the children with NP is higher than that of single detection.
Neonatal pneumoniaPoor prognosisBlood lactic acidHigh mobility group protein B1Prediction