首页|血乳酸、高迁移率族蛋白B1对新生儿肺炎预后不良的预测价值

血乳酸、高迁移率族蛋白B1对新生儿肺炎预后不良的预测价值

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目的:分析血乳酸、高迁移率族蛋白B1(HMGB1)对新生儿肺炎(NP)预后不良的预测价值.方法:选取 2021 年 3 月至 2023 年 3 月该院收治的 120 例NP患儿为研究对象,纳入观察组,另选取同期于本院出生的 120 名健康新生儿为对照组,检测两组血乳酸、HMGB1 水平.治疗后评估NP患儿的预后,比较不同预后NP患儿血乳酸、HMGB1 水平.绘制受试者工作特征(ROC)曲线分析血乳酸、HMGB1 单项及联合检测对NP患儿预后不良的预测价值.结果:观察组血乳酸、HMGB1 水平均高于对照组,差异有统计学意义(P<0.05);预后不良NP患儿血乳酸、HMGB1 水平均高于预后良好NP患儿,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血乳酸、HMGB1 单项及联合检测预测NP患儿预后不良的曲线下面积分别为 0.791、0.717、0.825,且联合检测高于二者单项检测,差异有统计学意义(P<0.05).结论:血乳酸、HMGB1 联合检测对NP患儿预后不良的预测价值高于二者单项检测.
Predictive value of blood lactic acid and high mobility group protein B1 for poor prognosis in children with neonatal pneumonia
Objective:To analyze predictive value of blood lactic acid and high mobility group protein B1(HMGB1)for poor prognosis in children with neonatal pneumonia(NP).Methods:A total of 120 children with NP admitted to the hospital from March 2021 to March 2023 were selected as the study subjects and included in the observation group.Another 120 healthy newborns born in this hospital during the same period were selected as the control group.The levels of blood lactic acid and HMGB1 in the two groups were detected.The prognosis of the NP children was judged,the levels of blood lactic acid and HMGB1 in the NP children with different prognosis were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of single and combined detection of blood lactic acid and HMGB1 for poor prognosis in the children with NP.Results:The levels of blood lactic acid and HMGB1 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of blood lactic acid and HMGB1 in the NP children with poor prognosis were higher than those in the NP children with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single blood lactic acid detection,single HMGB1 detection and combined detection for predicting poor prognosis of the NP children were 0.791,0.717 and 0.825,separately,the predictive value of combined detection was higher than that of single detection,and the differences were statistically significant(P<0.05).Conclusions:The predictive value of combined detection of blood lactic acid and HMGB1 for poor prognosis in the children with NP is higher than that of single detection.

Neonatal pneumoniaPoor prognosisBlood lactic acidHigh mobility group protein B1Prediction

张寅

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商丘市第一人民医院新生儿母婴同室,河南 商丘 476100

新生儿肺炎 预后不良 血乳酸 高迁移率族蛋白B1 预测

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(5)
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