Correlations among serum insulin-like growth factor-1,β-catenin,sex hormones,bone turnover biochemical marker levels and bone mineral density in patients with postmenopausal osteoporosis
Objective:To observe correlations among serum insulin-like growth factor-1(IGF-1),β-catenin,sex hormones,bone turnover biochemical marker levels and bone mineral density in patients with postmenopausal osteoporosis.Methods:A cross-sectional study was conducted on 82 patients with postmenopausal osteoporosis admitted to this hospital from August 2018 to March 2020,and they were set as osteoporosis group.60 postmenopausal women without osteoporosis who underwent physical examination in the hospital during the same period were selected for the cross-sectional study,and they were set as the control group.The levels of sex hormones[estradiol,luteinizing hormone(LH),follicle stimulating hormone(FSH),progesterone],bone mineral density,IGF-1,β-catenin,bone turnover biochemical markers[N-terminal propeptide of type 1 procollagen(PINP),β-collagen degradation product(β-CTX),N-terminal molecules of osteocalcin(N-BGP)]were compared between the two groups and among the patients with fracture and without fracture in the osteoporosis group.Pearson correlation analysis was used to analyze the correlations among the IGF-1,β-catenin,sex hormones,bone turnover biochemical marker levels and bone mineral density in the patients with postmenopausal osteoporosis.Results:The levels of estradiol,progesterone,bone mineral density,IGF-1 and β-catenin in the osteoporosis group were lower than those in the control group;the levels of LH,FSH,PINP,β-CTX and N-BGP were higher than those in the control group;and the differences were statistically significant(P<0.05).The incidence of fracture in the osteoporosis group was 36.59%(30/82).The levels of estradiol,progesterone,bone mineral density,serum IGF-1 and serum β-catenin in the fracture patients of osteoporosis group were significantly lower than those in the non-fracture patients,the levels of LH,FSH,PINP,β-CTX and N-BGP were significantly higher than those in the non-fracture patients,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum estradiol,progesterone,IGF-1 and β-catenin levels in the postmenopausal osteoporosis patients were positively correlated with bone mineral density(r>0,P<0.05);and the levels of LH,FSH,PINP,β-CTX and N-BGP were negatively correlated with bone mineral density(r<0,P<0.05).Conclusions:The levels of serum estradiol,progesterone,IGF-1 and β-catenin are positively correlated with bone mineral density in the patients with postmenopausal osteoporosis,and the levels of LH,FSH,PINP,β-CTX and N-BGP are negatively correlated with bone mineral density.
Insulin-like growth factor-1β-cateninSex hormoneBone turnover biochemical markerOsteoporosisBone mineral densityCorrelation
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