Effects of Tolvaptan combined with Levosimendan in treatment of patients with acute decompensated heart failure
Objective:To observe effects of Tolvaptan combined with Levosimendan in the treatment of patients with acute decompensated heart failure.Methods:The clinical data of 60 patients with acute decompensated heart failure admitted to this hospital from March 2020 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,30 cases in each group.Both groups were given conventional treatment.On this basis,the control group was treated with Levosimendan,while the study group was treated with Tolvaptan on the basis of that of the control group.The clinical efficacy,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVEDD)]levels and the serological indexes[brain natriuretic peptide(BNP),cardiac troponin I(cTnI)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.33%(28/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the level of LVEF in the study group was higher than that in the control group,the level of LVEDD was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of BNP and cTnI in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tolvaptan combined with Levosimendan in the treatment of the patients with acute decompensated heart failure can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of serological indexes.Moreover,it is superior to single Levosimendan treatment.
万方数据
维普
