Effects of Levosimendan combined with Dobutamine in treatment of patients with acute decompensated heart failure
Objective:To observe effects of Levosimendan combined with Dobutamine in treatment of patients with acute decompensated heart failure(ADHF).Methods:A prospective study was conducted on 80 patients with ADHF admitted to this hospital from March 2020 to October 2022.According to the random number table method,they were divided into control group and observation group,40 cases in each group.Both groups were given symptomatic treatment.On this basis,the control group was treated with Dobutamine,while the observation group was treated with Levosimendan on the basis of that of the control group.Both groups were treated for 5 d.The clinical efficacy,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)]levels and the serological indexes[brain natriuretic peptide(BNP),N-terminal brain natriuretic peptide precursor(NT-proBNP)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.50%(39/40),which was higher than 77.50%(31/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the level of LVEF in the observation group was higher than that in the control group,the levels of LVEDV and LVESV were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of BNP and NT-proBNP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Levosimendan combined with Dobutamine in the treatment of the ADHF patients can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of serological indexes.Moreover,it is superior to single Dobutamine treatment.
万方数据
维普
