Effects of Tolvaptan combined with Bisoprolol and Captopril in treatment of elderly patients with chronic heart failure
Objective:To investigate effects of Tolvaptan combined with Bisoprolol and Captopril in treatment of elderly patients with chronic heart failure(CHF).Methods:A prospective study was conducted on 82 elderly patients with CHF admitted to the hospital from January 2021 to May 2023.According to the random number table method,they were divided into control group and study group,41 cases in each group.The control group was treated with conventional anti-heart failure drugs(Bisoprolol fumarate tablets,Captopril tablets,and Hydrochlorothiazide tablets),while the study group was treated with Tolvaptan combined with Bisoprolol fumarate tablets and Captopril tablets.The clinical efficacy,the levels of cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],the levels of myocardial injury indexes[N-terminal pro-brain natriuretic peptide(NT-proBNP),heart-type fatty acid binding protein(H-FABP)]and ventricular remodeling indexes[matrix metalloproteinase(MMP)-2,MMP-9]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 87.80%(36/41),which was higher than 68.29%(28/41)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the level of LVEF in the study group was higher than that in the control group,the levels of LVEDD,LVESD,serum NT-proBNP,H-FABP,MMP-2 and MMP-9 were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tolvaptan combined with Bisoprolol and Captopril in the treatment of the elderly patients with CHF can effectively improve cardiac function and the total effective rate,reduce the myocardial injury and slow down the ventricular remodeling.Moreover,it is superior to conventional medication.
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