Effects of Ambroxol hydrochloride combined with Cefoperazone and Sulbactam in treatment of elderly patients with severe pneumonia
Objective:To observe effects of Ambroxol hydrochloride combined with Cefoperazone and Sulbactam in treatment of elderly patients with severe pneumonia.Methods:A prospective study was conducted on 120 elderly patients with severe pneumonia admitted to the hospital from January 2021 to January 2023.According to the random number table method,they were divided into study group and control group,60 cases in each group.The control group was treated with Cefoperazone and Sulbactam for injection,while the study group was treated with Ambroxol hydrochloride for injection on the basis of that of the control group.The clinical efficacy,the symptom disappearance time,the hospitalization time,the pulmonary infection[clinical pulmonary infection score(CPIS)]scores,the pulmonary function index[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]levels,the inflammatory factor[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.33%(56/60),which was higher than 80.00%(48/60)of the control group,and the difference was statistically significant(P<0.05).The cough disappearance time,the expectoration disappearance time,fever disappearance time,the lung wet rale disappearance time and the hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the CPIS scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FVC,FEV1 and FEV1/FVC in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-α and IFN-γ in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ambroxol hydrochloride combined with Cefoperazone and Sulbactam in the treatment of the elderly patients with severe pneumonia can improve the total effective rate of treatment and the levels of pulmonary function indexes,shorten the symptom disappearance time and the hospitalization time,and reduce the CPIS scores and the inflammatory factor levels.Moreover,it is superior to single Cefoperazone and Sulbactam treatment.
ElderlySevere pneumoniaAmbroxol hydrochlorideCefoperazone and SulbactamLung functionInflammatory factor
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