Effects of Vonoprazan combined with Lansoprazole in treatment of patients with gastroesophageal reflux disease
Objective:To observe effects of Vonoprazan combined with Lansoprazole in the treatment of patients with gastroesophageal reflux disease(GERD).Methods:A prospective study was conducted on 102 patients with GERD admitted to this hospital from July 2021 to July 2022.According to the random number table method,they were divided into observation group and control group,51 cases in each group.The control group was treated with Lansoprazole enteric-coated tablets,while the observation group was treated with Vonoprazan tablets on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[interleukin(IL)-6,IL-1β,tumor necrosis factor-α(TNF-α)],the degree of esophageal mucosal injury,the reflux conditions before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.08%(49/51),which was higher than 84.31%(43/51)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-6,IL-1β and TNF-α in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the degree of esophageal mucosal injury in the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the number of acid reflux in the two groups were less than those before the treatment,and that in the observation group was less than that in the control group;the longest reflux time in the two groups were shorter than those before the treatment,and that in the observation group was shorter than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Vonoprazan combined with Lansoprazole in the treatment of the GERD patients can improve the total effective rate of treatment,reduce the number of reflux,shorten the longest reflux time,and reduce the levels of inflammatory factors and the degree of esophageal mucosal injury.Moreover,it is superior to single Lansoprazole enteric-coated tablets treatment.
Gastroesophageal refluxVonoprazanLansoprazoleInflammatory factorDegree of esophageal mucosal injuryAdverse reaction
万方数据
维普
