Application effects of modified hypothermia combined with permissive hypotensive resuscitation strategy in emergency abdominal trauma patients with hemorrhagic shock
Objective:To observe application effects of modified hypothermia combined with permissive hypotensive resuscitation strategy in emergency abdominal trauma patients with hemorrhagic shock.Methods:The clinical data of 68 patients with emergency abdominal trauma and hemorrhagic shock admitted to this hospital from February 2020 to May 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=34)and observation group(n=34).The control group was treated with permissive hypotensive resuscitation strategy,while the observation group was treated with modified hypothermia on the basis of that of the control group.The levels of thrombelastogram indexes[coagulation reaction time(R),coagulation final strength(MA),coagulation time(K),α angle]levels,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-10(IL-10)]levels,pain mediators[substance P(SP),prostaglandin E2(PGE2),dopamine(DA)]levels,and the incidence of adverse reactions during hospitalization were compared between the two groups before and after the treatment.Results:After the treatment,the levels of R and K in the observation group were shorter than those in the control group,the levels of MA and α angle were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the serum IL-10 level in the observation group was higher than that in the control group,the TNF-α level was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum SP,PGE2 and DA in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:The modified hypothermia combined with permissive hypotensive resuscitation strategy in the emergency abdominal trauma patients with hemorrhagic shock can improve the levels of thrombelastogram indexes and inflammatory factors,and reduce the levels of pain mediators.Moreover,it is superior to single permissive hypotensive resuscitation strategy.
万方数据
维普
