Effects of Ketorolac tromethamine injection combined with Sufentanil citrate injection on patient-controlled intravenous analgesia after total knee arthroplasty
Objective:To observe effects of Ketorolac tromethamine injection combined with Sufentanil citrate injection on patient-controlled intravenous analgesia after total knee arthroplasty.Methods:A prospective study was conducted on 120 patients after total knee arthroplasty admitted to the hospital from January 2020 to January 2022.According to the random number table method,they were divided into observation group(n=60)and control group(n=60).The postoperative patient-controlled intravenous analgesia was performed in both groups.The control group was treated with Sufentanil citrate injection,while the observation group was treated with Ketorolac tromethamine injection combined with Sufentanil citrate injection.The pain visual analogue scale(VAS)score,the serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)]levels,the mini-mental state examination scale(MMSE)score,and the incidence of adverse reactions were compared between the two groups.Results:2,4,8,24 and 48 h after the surgery,there were no significant differences in the VAS scores between the two group in resting state and active(cough)state(P>0.05).24 h after the surgery,the levels of serum IL-6,hs-CRP and TNF-α in the two groups were higher than those before the surgery,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).4 and 8 h after the surgery,the MMSE scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Further,48 h after the surgery,the incidence of adverse reactions in the observation group was 21.67%,which was lower than 43.33%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Ketorolac tromethamine injection combined with Sufentanil citrate injection for patient-controlled intravenous analgesia after total knee arthroplasty can improve the MMSE scores,reduce the incidence of adverse reactions and the inflammatory factor levels.Moreover,it is superior to Sufentanil citrate injection intravenous patient-controlled analgesia.
Total knee arthroplastyPostoperativePatient-controlled intravenous analgesiaKetorolac tromethamineSufentanil citrateMMSE scoreInflammatory factor
万方数据
维普
