Effects of GnRH-a combined with Prednisolone acetate in treatment of patients with endometriosis complicated with habitual abortion
Objective:To observe effects of gona-dotropin-releasing hormone agonist(GnRH-a)combined with Prednisolone acetate in treatment of patients with endometriosis complicated with habitual abortion.Methods:A prospective study was conducted on 105 patients with endometriosis complicated with habitual abortion admitted to the hospital from January 2020 to January 2023.According to the random number table method,they were divided into study group(n=53)and control group(n=52).The control group was treated with Prednisolone acetate,while the study group was treated with GnRH-a on the basis of that of the control group.The clinical efficacy,the ovarian function indexes[follicle stimulating hormone(FSH),luteinizing hormone(LH)]level,the endometrial related parameters[resistance index(RI),pulsatility index(PI)]levels,the monocyte chemoattractant protein-1(MCP-1)level,the vascular endothelial growth factor(VEGF)level before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 90.57%(48/53),which was higher than 73.08%(38/52)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FSH,LH,RI and PI in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of VEGF and MCP-1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions:GnRH-a combined with Prednisolone acetate in the treatment of the patients with endometriosis complicated with habitual abortion can improve the clinical efficacy,improve the ovarian function and the levels of endometrial RI and PI,and reduce the VEGF and MCP-1 levels.Moreover,it is superior to single Prednisolone acetate treatment.
Prednisolone acetateGonadotropin releasing hormone agonistEndometriosisHabitual abortionOvarian function
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