Effects of Qigui Huatan Xiaogeng decoction combined with Butylphthalide in treatment of patients with acute cerebral infarction
Objective:To observe effects of Qigui Huatan Xiaogeng decoction combined with Butylphthalide in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 168 patients with acute cerebral infarction admitted to this hospital from February 2020 to January 2023.According to the random number table method,they were divided into control group and observation group,84 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with Butylphthalide,while the observation group was treated with Qigui Huatan Xiaogeng decoction on the basis of that of the control group.Both groups were treated for 14 d.The clinical efficacy,the Traditional Chinese Medicine(TCM)syndrome score,the hemorheology indexes[plasma viscosity(PV),whole blood high shear viscosity(HBV)]levels,the serological indexes[high-sensitivity C-reactive protein(hs-CRP),central nervous system specific protein(S100β),insulin-like growth factor-1(IGF-1)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.43%(81/84),which was higher than 86.90%(73/84)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as main symptoms and secondary symptoms in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PV and HBV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP and S100β in the observation group were lower than those in the control group,the level of IGF-1 was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Qigui Huatan Xiaogeng decoction combined with Butylphthalide in the treatment of patients with acute cerebral infarction can improve the total effective rate of treatment,reduce the TCM syndrome scores and the hemorheology index levels,and improve the serological index levels.Moreover,it is superior to single Butylphthalide treatment.