首页|芪归化痰消梗汤联合丁苯酞治疗脑梗死急性期患者的效果

芪归化痰消梗汤联合丁苯酞治疗脑梗死急性期患者的效果

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目的:观察芪归化痰消梗汤联合丁苯酞治疗脑梗死急性期患者的效果.方法:选取 2020 年 2 月至 2023 年 1 月该院收治的168 例脑梗死急性期患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各 84 例.两组均进行常规治疗,在此基础上,对照组予以丁苯酞治疗,观察组在对照组基础上联合芪归化痰消梗汤治疗,两组均连续治疗14 d.比较两组临床疗效,治疗前后中医证候积分、血液流变学指标[血浆黏度(PV)、全血高切黏度(HBV)]水平、血清学指标[超敏C反应蛋白(hs-CRP)、中枢神经特异性蛋白(S100β)、胰岛素样生长因子-1(IGF-1)]水平,以及不良反应发生率.结果:观察组治疗总有效率为96.43%(81/84),高于对照组的86.90%(73/84),差异有统计学意义(P<0.05);治疗后,观察组主症、次症等中医证候积分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组PV、HBV水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组hs-CRP、S100β水平均低于对照组,IGF-1 水平高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:芪归化痰消梗汤联合丁苯酞治疗脑梗死急性期患者可提高治疗总有效率,降低中医证候积分和血液流变学指标水平,改善血清学指标水平,效果优于单纯丁苯酞治疗.
Effects of Qigui Huatan Xiaogeng decoction combined with Butylphthalide in treatment of patients with acute cerebral infarction
Objective:To observe effects of Qigui Huatan Xiaogeng decoction combined with Butylphthalide in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 168 patients with acute cerebral infarction admitted to this hospital from February 2020 to January 2023.According to the random number table method,they were divided into control group and observation group,84 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with Butylphthalide,while the observation group was treated with Qigui Huatan Xiaogeng decoction on the basis of that of the control group.Both groups were treated for 14 d.The clinical efficacy,the Traditional Chinese Medicine(TCM)syndrome score,the hemorheology indexes[plasma viscosity(PV),whole blood high shear viscosity(HBV)]levels,the serological indexes[high-sensitivity C-reactive protein(hs-CRP),central nervous system specific protein(S100β),insulin-like growth factor-1(IGF-1)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.43%(81/84),which was higher than 86.90%(73/84)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as main symptoms and secondary symptoms in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PV and HBV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP and S100β in the observation group were lower than those in the control group,the level of IGF-1 was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Qigui Huatan Xiaogeng decoction combined with Butylphthalide in the treatment of patients with acute cerebral infarction can improve the total effective rate of treatment,reduce the TCM syndrome scores and the hemorheology index levels,and improve the serological index levels.Moreover,it is superior to single Butylphthalide treatment.

Cerebral infarctionAcute phaseQigui Huatan Xiaogeng decoctionButylphthalideTCM syndrome scoreHemorheologyAdverse reaction

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新野县中医院内一科,河南 南阳 473500

脑梗死 急性期 芪归化痰消梗汤 丁苯酞 中医证候积分 血液流变学 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(6)
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