Effects of Zhufu decoction combined with Trimetazidine in treatment of patients with heart failure after percutaneous coronary intervention
Objective:To observe effects of Zhufu decoction combined with Trimetazidine in treatment of patients with heart failure after percutaneous coronary intervention(PCI).Methods:A prospective study was conducted on 62 patients with heart failure after PCI admitted to the hospital from June 2020 to December 2022.According to the random number table method,they were divided into control group and observation group,31 cases in each group.Both groups were given anti-heart failure basic treatment.On this basis,the control group was treated with Trimetazidine,while the observation group was treated with Zhufu decoction on the basis of that of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,the Traditional Chinese Medicine(TCM)syndrome score,the cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),left ventricular fractional shortening(LVFS)]levels,the serological indexes[N-terminal pro-brain natriuretic peptide(NT-proBNP),soluble suppression of tumorigenicity 2(sST2),growth differentiation factor-15(GDF-15)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.55%(29/31),which was higher than 74.19%(23/31)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as palpitation and asthma,facial edema,irritability and sweating,and purple lips in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of LVESD in the observation group was lower than that in the control group,the levels of LVFS and LVEF were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NT-proBNP,sST2 and GDF-15 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).During the treatment,there were no obvious adverse reactions in the two groups.Conclusions:Zhufu decoction combined with Trimetazidine in the treatment of the patients with heart failure after PCI can improve the total effective rate of treatment,reduce the TCM syndrome scores and serological index levels,and improve the levels of cardiac function indexes.Moreover,it is superior to single Trimetazidine treatment.
Zhufu decoctionTrimetazidinePercutaneous coronary interventionHeart failureTCM syndrome scoreCardiac function
万方数据
维普
