Effects of Xiaoer Chiqiao Qingre granules combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia
Objective:To investigate effects of Xiaoer Chiqiao Qingre granules combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods:The clinical data of 60 children with MPP admitted to this hospital from September 2020 to September 2023 were retrospectively analyzed.According to different treatment methods,these children were divided into control group and observation group,30 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with Xiaoer Chiqiao Qingre granules on the basis of that of the control group.The clinical efficacy,the levels of serum inflammatory factors[interleukin(IL)-6,IL-8,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],humoral immune indexes[immunoglobulin(Ig)A,IgG,IgM]and cellular immune indexes(CD3+,CD4+,CD8+,CD4+/CD8+)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:There was no significant difference in the total effective rate between the two groups(P>0.05).The cure rate of the observation group was 70.00%(21/30),which was higher than 43.33%(13/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum IL-6,IL-8,TNF-α,CRP and CD8+ in the observation group were lower than those in the control group,the levels of IgA,IgG,IgM,CD3+,CD4+ and CD4+/CD8+ were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xiaoer Chiqiao Qingre granules combined with Azithromycin has a significant effect in the treatment of the children with MPP,which can reduce the levels of inflammatory factors and improve the humoral and cellular immune function.Moreover,it is superior to single Azithromycin treatment.
Mycoplasma pneumoniae pneumoniaChildrenXiaoer Chiqiao Qingre granulesAzithromycinInflammatory factorImmune function
万方数据
维普
