Efficiency of combined detection of serum uric acid and cystatin C levels in diagnosis of diabetic nephropathy in patients with type 2 diabetes
Objective:To analyze efficiency of combined detection of serum uric acid(SUA)and cystatin C(CysC)levels in diagnosis of diabetic nephropathy(DN)in patients with type 2 diabetes.Methods:110 patients with type 2 diabetes admitted to the hospital from April 2022 to April 2023 were selected for the prospective study and included in the observation group.In addition,110 healthy people who underwent routine physical examination in this hospital during the same period were selected as the control group.The levels of SUA and CysC in the two groups were detected.The occurrence of DN in patients with type 2 diabetes was statistically analyzed.The levels of SUA and CysC in the patients with DN and those without DN were compared.The receiver operating characteristic curve(ROC)was drawn to analyze the efficiencies of single and combined detection of SUA and CysC levels in the diagnosis of DN.Results:The levels of SUA and CysC in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of SUA and CysC in the patients with DN were higher than those in the patients without DN,and the differences were statistically significant(P<0.05).ROC curve results showed that the areas under the curve of single SUA level detection,single CysC level detection and combined detection in the diagnosis of DN in the patients with type 2 diabetes were 0.809,0.804 and 0.882,separately,which had certain diagnostic efficiency,and the diagnostic efficiency of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of SUA and CysC levels in the diagnosis of DN in the patients with type 2 diabetes is higher than that of single detection.
Type 2 diabetesDiabetic nephropathyBlood uric acidCystatin CDiagnostic efficiency
万方数据
维普
