首页|康柏西普与曲安奈德玻璃体腔注射治疗糖尿病视网膜病变患者的效果比较

康柏西普与曲安奈德玻璃体腔注射治疗糖尿病视网膜病变患者的效果比较

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目的:比较康柏西普与曲安奈德玻璃体腔注射治疗糖尿病视网膜病变患者的效果.方法:选取 2019 年 8 月至 2022 年 8 月该院收治的 88 例糖尿病视网膜病变患者进行前瞻性研究,按照随机数字表法将其分为对照组(n=44,共 77 眼)和研究组(n=44,共88眼).对照组采用曲安奈德玻璃体腔注射治疗,研究组采用康柏西普玻璃体腔注射治疗.比较两组治疗前后最佳矫正视力(BCVA)水平、视功能指标[黄斑中心凹视网膜厚度(CMT)、黄斑中心凹无血管区(FAZ)]水平、眼内液指标[一氧化氮合酶(NOS)、血管内皮生长因子(VEGF)]水平,以及不良反应发生率.结果:治疗 1、3 个月后,研究组BVCA水平均高于对照组,差异有统计学意义(P<0.05);治疗3个月后,研究组CMT、FAZ水平均低于对照组,差异有统计学意义(P<0.05);治疗3个月后,研究组眼内液NOS水平高于对照组,VEGF水平低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为 6.82%(3/44),低于对照组的 22.73%(10/44),差异有统计学意义(P<0.05).结论:康柏西普玻璃体腔注射治疗糖尿病视网膜病变患者可改善视力、视功能指标和眼内液指标水平,且安全性较高,效果优于曲安奈德玻璃体腔注射治疗.
Comparison of effects of intravitreal injection of Conbercept and Triamcinolone acetonide on patients with diabetic retinopathy
Objective:To compare effects of intravitreal injection of Conbercept and Triamcinolone acetonide on patients with diabetic retinopathy.Methods:A prospective study was conducted on 88 patients with diabetic retinopathy admitted to this hospital from August 2019 to August 2022.According to the random number table method,they were divided into control group(n=44,77 eyes)and study group(n=44,88 eyes).The control group was treated with intravitreal injection of Triamcinolone acetonide,while the study group was treated with intravitreal injection of Conbercept.The best corrected visual acuity(BCVA)level,the visual function index[central macular thickness(CMT),macular foveal avascular zone(FAZ)]levels,the intraocular fluid index[nitric oxide synthase(NOS),vascular endothelial growth factor(VEGF)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After 1 and 3 months of treatment,the levels of BVCA in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of CMT and FAZ in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the level of NOS in the intraocular fluid of the study group was higher than that of the control group,the level of VEGF was lower than that of the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 6.82%(3/44),which was lower than 22.73%(10/44)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Intravitreal injection of Conbercept in the treatment of the patients with diabetic retinopathy can improve the visual acuity and the levels of the visual function indexes and the intraocular fluid indexes,and has good safety.Moreover,it is superior to intravitreal injection of Triamcinolone acetonide.

Diabetic retinopathyConberceptTriamcinolone acetonideBest corrected visual acuityVisual functionAdverse reaction

李艳艳

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宝丰县人民医院眼科,河南 平顶山 467400

糖尿病视网膜病变 康柏西普 曲安奈德 最佳矫正视力 视功能 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(6)
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