Effects of Amiodarone combined with Metoprolol in treatment of patients with chronic heart failure and ventricular premature beats
Objective:To observe effects of Amiodarone combined with Metoprolol in treatment of patients with chronic heart failure(CHF)and ventricular premature beats.Methods:A retrospective analysis was conducted on the clinical data of 92 patients with CHF complicated with ventricular premature beats admitted to the hospital from April 2022 to April 2023.According to different treatment methods,they were divided into control group and study group,46 cases in each group.The control group was treated with Metoprolol,while the study group was treated with Amiodarone on the basis of that of the control group.The therapeutic effects,the levels of heart rate variability indicators[standard deviation of NN intervals(SDNN),root mean square successive differences between successive R-R intervals(RMSSD),standard deviation of the average NN intervals(SDANN)],premature beat frequency,the levels of cardiac function indicators[left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],the levels of endothelial function indicators[nitric oxide(NO),endothelin-1(ET-1),calcitonin gene related peptide(CGRP),brachial artery endothelial dependent vasodilation function(FMD)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.48%(43/46),which was higher than 65.22%(30/46)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of SDNN,RMSSD,and SDANN in both groups were higher than those before the treatment,and the study group were higher than those of the control group;the frequency of premature beats in both groups were lower than those before the treatment,and the study group was lower than the control group;and the difference was statistically significant(P<0.05).After the treatment,the LVEDD and LVESD levels in both groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the LVEF levels in both groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of FMD,NO,and CGRP in both groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of ET-1 in both groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Amiodarone combined with Metoprolol in the treatment of the CHF patients with ventricular premature beats can improve the total effective rate and the heart rate variability indicator levels,and improve the levels of cardiac function indicators,vascular endothelial function indicators,and reduce the premature beat frequency.Moreover,it is superior to single Metoprolol treatment.
NETL
NSTL
万方数据
维普
