Effects of Idebenone combined with Levodopa in treatment of patients with Parkinson's disease
Objective:To observe effects of Idebenone combined with Levodopa in treatment of patients with Parkinson's disease.Methods:A prospective study was conducted on 68 patients with Parkinson's disease admitted to the hospital from February 2021 to February 2023.According to the random number table method,they were divided into control group and observation group,34 cases in each group.The control group was treated with Levodopa,while the observation group was treated with Idebenone on the basis of that of the control group.Both groups were treated for 12 weeks.The clinical efficacy,the cognitive function[Montreal cognitive assessment(MoCA)]score,the motor function[unified Parkinson's disease rating scale Part III(UPDRS III)]score,the oxidative stress indexes[superoxide dismutase(SOD),8-hydroxydeoxyguanosine(8-OHDG),malondialdehyde(MDA)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 97.06%(33/34),which was higher than that of the control group 76.47%(26/34),and the difference was statistically significant(P<0.05).After the treatment,the MoCA score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the UPDRS III score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of MDA and 8-OHDG in the observation group were lower than those in the control group,the level of SOD was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Idebenone combined with Levodopa in the treatment of the Parkinson's disease patients can improve the total effective rate of treatment,the cognitive function scores,reduce the motor function scores,and improve the levels of oxidative stress indexes.Moreover,it is superior to single Levodopa treatment.
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NSTL
万方数据
维普
