Effects of Bifidobacterium quadruple viable tablets combined with Loperamide in treatment of patients with diarrhea-predominant irritable bowel syndrome
Objective:To investigate effects of Bifidobacterium quadruple viable tablets combined with Loperamide in treatment of patients with diarrhea-predominant irritable bowel syndrome(IBS-D).Methods:A prospective study was conducted on 70 patients with IBS-D admitted to this hospital from January 2021 to January 2023.According to the random number table method,they were divided into control group and observation group,35 cases in each group.The control group was treated with oral Loperamide capsules,while the observation group was treated with oral Bifidobacterium quadruple viable tablets on the basis of that of the control group.The clinical efficacy,the levels of serum inflammatory factors[interleukin(IL)-2,IL-6 and tumor necrosis factor-α(TNF-α)],the clinical symptom scores and the number of intestinal flora before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.14%(34/35),which was higher than 77.14%(27/35)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of abdominal pain,abdominal distension,stool traits,stool frequency and the serum IL-2,IL-6 and TNF-α levels in the observation group were lower than those in the control group,the number of Bifidobacteria and Lactobacilli were higher than those in the control group,the number of Enterobacteria and Enterococcus were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bifidobacterium quadruple viable tablets combined with Loperamide is effective in the treatment of the IBS-D patients,which can accelerate the symptom relief,restore the balance of intestinal flora and reduce the levels of inflammatory factors.Moreover,it is superior to single Loperamide treatment.