Effects of L-carnitine combined with human erythropoietin in treatment of maintenance hemodialysis patients with renal anemia
Objective:To observe effects of L-carnitine combined with human erythropoietin in the treatment of maintenance hemodialysis patients with renal anemia.Methods:A prospective study was conducted on 80 patients with maintenance hemodialysis and renal anemia admitted to this hospital from January 2021 to May 2023.According to the random number table method,they were divided into control group and observation group,40 cases in each group.The control group was treated with human erythropoietin,while the observation group was treated with levocarnitine on the basis of that of the control group.The clinical efficacy,the levels of anemia indexes[hemoglobin(Hb),prealbumin(PA),serum calcium,serum phosphorus],the levels of renal function indexes[serum creatinine(Scr),β2-microglobulin(β2-MG),transforming growth factor-β1(TGF-β1),cystatin C(Cys-C)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.50%(39/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Hb,PA and serum calcium in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the blood phosphorus levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of Scr,β2-MG,TGF-β1 and Cys-C in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:L-carnitine combined with human erythropoietin in the treatment of the maintenance hemodialysis patients with renal anemia can improve the total effective rate of treatment,improve the levels of anemia indexes,and reduce the levels of renal function indexes.Moreover,it is superior to single human erythropoietin treatment.
NETL
NSTL
万方数据
维普
