Effects of Leflunomide combined with Prednisone in treatment of lupus nephritis
Objective:To observe effects of Leflunomide combined with Prednisone in treatment of patients with lupus nephritis.Methods:A prospective study was conducted on 90 patients with lupus nephritis admitted to the hospital from June 2021 to February 2023.According to the random number table method,they were divided into observation group and control group,45 cases in each group.The control group was treated with Prednisone,while the observation group was treated with Leflunomide on the basis of that of the control group.Both groups were treated continuously for 6 months.The clinical efficacy,the renal function indexes[24 h urine protein quantification,serum creatinine(Scr),blood urea nitrogen(BUN)]levels,the inflammatory indexes[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels,the systemic lupus erythematosus disease activity(SLEDAI)score,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 93.33%(42/45),which was higher than 77.78%(35/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of 24 h urinary protein,Scr and BUN in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6 and TNF-α in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the SLEDAI score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Leflunomide combined with Prednisone in the treatment of the patients with lupus nephritis can improve the total effective rate of treatment and reduce the levels of renal function indexes and inflammatory indexes and the SLEDAI scores.Moreover,it is superior to single Prednisone treatment.
NETL
NSTL
万方数据
维普
