Effects of GnRHa combined with laparoscopic surgery in treatment of patients with endometriosis
Objective:To observe effects of gonadotropin releasing hormone agonist(GnRHa)combined with laparoscopic surgery in treatment of patients with endometriosis(EMT).Methods:A prospective study was conducted on 106 patients with EMT admitted to the department of obstetrics and gynecology of the hospital from January 2021 to May 2022.They were divided into control group(n=53)and observation group(n=53)by using the random number table method.The control group was treated with laparoscopic surgery,while the observation group was treated with GnRHa on the basis of that of the control group.The clinical efficacy,the ovarian function indexes[estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH)]levels before and after the treatment,the incidence of adverse reactions during treatment,and the dysmenorrhea rate and the pregnancy rate after 12 months of follow-up were compared between the two groups.Results:The total effective rate of the observation group was 90.57%(48/53),which was higher than 75.47%(40/53)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of E2,LH and FSH in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 12 months of follow-up,the dysmenorrhea rate of the observation group was lower than that of the control group,the pregnancy rate was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusions:GnRHa combined with laparoscopic surgery in the treatment of the EMT patients can improve the total effective rate and the pregnancy rate,and reduce the levels of ovarian function indexes and the dysmenorrhea rate.Moreover,it is superior to single laparoscopic surgery.
NETL
NSTL
万方数据
维普
