Effects of Xuezhikang capsules combined with Amlodipine and Atorvastatin calcium in treatment of patients with hypertension complicated with coronary heart disease
Objective:To observe effects of Xuezhikang capsules combined with Amlodipine and Atorvastatin calcium in treatment of patients with hypertension complicated with coronary heart disease.Methods:A prospective study was conducted on 150 patients with hypertension and coronary heart disease admitted to this hospital from March 2021 to February 2023.According to the random number table method,they were divided into study group and control group,75 cases in each group.The control group was treated with Atorvastatin calcium tablets combined with Amlodipine sulfonate tablets,while the study group was treated with Xuezhikang capsules on the basis of those of the control group.The clinical efficacy,the cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)]levels,the myocardial injury markers[creatine kinase isoenzyme(CK-MB),troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP)]levels,the lipid metabolism indexes[total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)]levels before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 92.00%(69/75),which was higher than 80.00%(60/75)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVESD and LVEDD in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of cTnI,CK-MB and NT-proBNP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of TC,TG and LDL-C in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the HDL-C levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xuezhikang capsules combined with Amlodipine and Atorvastatin calcium in the treatment of the patients with hypertension and coronary heart disease can improve the total effective rate of treatment,improve the levels of lipid metabolism indexes,and reduce the levels of cardiac function indexes and myocardial injury markers.Moreover,it is superior to Atorvastatin calcium tablets combined with Amlodipine sulfonate tablets treatment.
NETL
NSTL
万方数据
维普
