Effects of Kangfuxin liquid enema combined with Mesalazine in treatment of ulcerative colitis
Objective:To observe effects of Kangfuxin liquid enema combined with Mesalazine in treatment of ulcerative colitis.Methods:A prospective study was conducted on 96 patients with ulcerative colitis admitted to the hospital from June 2022 to August 2023.According to the random number table method,they were divided into study group and control group,48 cases in each group.The control group was treated with Mesalazine enteric-coated tablets,while the study group was treated with Kangfuxin liquid enema on the basis of that of the control group.The clinical efficacy,the inflammatory factor levels[soluble intercellular adhesion molecule-1(sICAM-1),soluble receptor for advanced glycation end products(sRAGE)],the colonic mucosal lesion degree(modified Mayo score),the colonic lesion index levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 91.67%(44/48),which was higher than 77.08%(37/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of sRAGE and sICAM-1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The modified Mayo scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).The colonic mucosal blood flow levels of the two groups were higher than those before the treatment,and that of the study group was higher than that of the control group;the ulcer diameter levels of the two groups were smaller than those before the treatment,that in the study group was smaller than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Kangfuxin liquid enema combined with Mesalazine in the treatment of the patients with ulcerative colitis can improve the total effective rate of treatment,improve the levels of colon lesion indexes,reduce the levels of inflammatory factors and the modified Mayo scores.Moreover,it is superior to single Mesalazine treatment.
Kangfuxin liquidEnemaMesalazineUlcerative colitisInflammatory indicatormodified Mayo scoreAdverse reaction
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NSTL
万方数据
维普
