Application effects of Kanglaite injection combined with chemotherapy in patients with advanced lung cancer
Objective:To observe application effects of Kanglaite injection combined with chemotherapy in patients with advanced lung cancer.Methods:A prospective study was conducted on 86 patients with advanced lung cancer admitted to the hospital from October 2019 to October 2022.According to the random number table method,they were divided into observation group and control group,43 cases in each group.The control group was treated with chemotherapy,while the observation group was treated with Kanglaite injection on the basis of that of the control group.The objective remission rate(ORR),the tumor markers[neuron-specific enolase(NSE),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)]levels,the lung function indexes[maximum ventilation volume(MVV),forced vital capacity(FVC),forced expiratory volume in one second(FEV1)]levels,the visual analogue scale(VAS)score,and the incidence of adverse reactions during treatment were compared between the two groups before and after the treatment.Results:The ORR of the observation group was 67.44%(29/43),which was higher than 44.19%(19/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of NSE,CA125 and CEA in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of MVV,FVC and FEV1 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the VAS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 9.30%(4/43),which was lower than 25.58%(11/43)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Kanglaite injection combined with chemotherapy in the patients with advanced lung cancer can improve the levels of ORR and lung function indexes and reduce the levels of tumor markers,the VAS scores and the incidence of adverse reactions.Moreover,it is superior to single chemotherapy.