differential diagnosis efficiency of contrast-enhanced ultrasound combined with ultrasound elastography in distinguishing benign and malignant breast nodules with clinical palpation negative
Objective:To explore differential diagnostic efficiency of contrast-enhanced ultrasound combined with ultrasound elastography in distinguishing benign and malignant breast nodules with clinical palpation negative.Methods:The clinical data of 120 patients with clinical palpation negative breast nodules who were treated in the hospital from June 2020 to June 2022 were retrospectively analyzed.The contrast-enhanced ultrasound parameters[peak intensity(PI),wash in slope(WIS),area under the curve(AUC),time to peak(TTP)]levels,the ultrasound elastography parameters[area percentage of blue area(AREA%),mean strain of interest(MEAN)and standard deviation(SD)]of benign and malignant nodules were compared.Using the pathological results as the gold standard,the efficiencies of contrast-enhanced ultrasound,ultrasound elastography single and combination examinations for the differential diagnosis of benign and malignant breast nodules with clinical palpation negative.Results:The pathological examination showed that there were 74 cases(61.67%)of malignant nodules and 46 cases(38.33%)of benign nodules in the 120 patients with palpation negative breast nodules.The levels of PI,WIS,AUC,AREA%,MEAN and SD of the malignant nodules were higher than those of the benign nodules,the TTP value was lower than that of the benign nodules,and the differences were statistically significant(P<0.05).The sensitivity and the accuracy of combined examination of contrast-enhanced ultrasound and ultrasound elastography in diagnosing clinical palpable negative breast malignant nodules were higher than those of single diagnosis,and the differences were statistically significant(P<0.05).There was no significant difference in the specificity of single and combined examination of contrast-enhanced ultrasound and ultrasound elastography in diagnosing clinical palpable negative breast malignant nodules(P>0.05).Conclusions:Contrast-enhanced ultrasound and ultrasonic elastography have certain diagnostic value for clinical palpation negative breast nodules.Further,the sensitivity and the accuracy of combined diagnosis are higher than those of single contrast-enhanced ultrasound and singe ultrasound elastography.
NETL
NSTL
万方数据
维普
