Comparison of effects of Sacubitril/Valsartan and Irbesartan combined with Amlodipine in treatment of diabetic nephropathy complicated with hypertension
Objective:To compare effects of Sacubitril/Valsartan and Irbesartan combined with Amlodipine in treatment of diabetic nephropathy(DN)patients with hypertension.Methods:A prospective study was conducted on 90 patients with DN complicated with hypertension admitted to the hospital from January 2021 to January 2023.According to the random number table method,they were divided into control group and observation group,45 cases in each group.The control group was treated with Irbesartan combined with Amlodipine,while the observation group was treated with Sacubitril/Valsartan combined with Amlodipine.The clinical efficacy,the blood pressure indexes[systolic blood pressure(SBP),diastolic blood pressure(DBP)]levels,the blood glucose indexes[fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),postprandial 2h blood glucose(2hPG)]levels,the renal function indexes[creatinine(Scr),blood urea nitrogen(BUN),24h urine protein(24hUP),cystatin C(CysC)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:There was no significant difference in the total effective rate between the two groups(P>0.05).After the treatment,the levels of SBP and DBP in the two groups were lower than those before the treatment,but there were no significant differences between the two groups(P>0.05).The levels of FPG,2hPG and HbAlc in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of Scr,BUN,24hUP and CysC in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:The antihypertensive effect of Sacubitril/Valsartan and Irbesartan combined with Amlodipine in the treatment of the DN patients with hypertension is similar,but Sacubitril/Valsartan combined with Amlodipine can reduce the levels of blood glucose indexes and renal function indexes,and it is superior to Irbesartan combined with Amlodipine.
Diabetic nephropathyHypertensionAmlodipine besylateIrbesartanSacubitril/ValsartanBlood glucoseRenal function
NETL
NSTL
万方数据
维普
