Effects of recombinant human brain natriuretic peptide combined with Levosimendan in treatment of patients with acute heart failure
Objective:To investigate effects of recombinant human brain natriuretic peptide(rhBNP)combined with Levosimendan in treatment of patients with acute heart failure(AHF).Methods:The clinical data of 96 patients with AHF admitted to this hospital from January 2022 to May 2023 were retrospectively analyzed.According to the different treatment methods,they were divided into control group and study group,48 cases in each group.The control group was treated with Levosimendan injection,while the study group was treated with rhBNP for injection on the basis of that of the control group.The clinical efficacy,the cardiac function indexes[stroke volume(SV),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)]levels,the myocardial injury indexes[creatine kinase(CK),brain natriuretic peptide(BNP)],hemodynamics[heart rate,mean arterial pressure(MAP)]levels,and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 93.75%(45/48),which was higher than 79.17%(38/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of MAP,SV and LVEF in the study group were higher than those in the control group,the levels of heart rate,LVEDD,LVESD,CK and BNP were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:rhBNP combined with Levosimendan in the treatment of the AHF patients is helpful to improve the clinical efficacy,improve the cardiac function,reduce the myocardial injury and improve the levels of hemodynamic indexes.Moreover,it is superior to single Levosimendan treatment.
Acute heart failureRecombinant human brain natriuretic peptideLevosimendanCardiac function
NETL
NSTL
万方数据
维普
