Effects of Dapagliflozin combined with conventional drugs in treatment of patients with hypertension and type 2 diabetes
Objective:To observe effects of Dapagliflozin combined with conventional drugs in treatment of patients with hypertension and type 2 diabetes.Methods:The clinical data of 96 patients with hypertension and type 2 diabetes admitted to this hospital from May 2021 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,48 cases in each group.The control group was treated with conventional drugs(Captopril + Metformin),while the study group was treated with Dapagliflozin on the basis of that if the control group.Both groups were treated continuously for 12 weeks.The clinical efficacy,the blood glucose indexes[fasting blood glucose(FBG),2 h postprandial blood glucose(2hPG)]levels,the high-density lipoprotein cholesterol(HDL-C)level,the vascular endothelial function indexes[soluble vascular cell adhesion molecule-1(sVCAM-1),monocyte chemoattractant protein-1(MCP-1)]levels,the arteriosclerosis indexes[carotid intima-media thickness(IMT),brachial artery blood flow-mediated vasodilation function(FMD)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 97.92%(47/48),which was higher than 83.33%(40/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FBG and 2hPG in the study group were lower than those in the control group,the level of HDL-C was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of sVCAM-1 and MCP-1 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the IMT level of the study group was lower than that of the control group,the FMD level was higher than that of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dapagliflozin combined with conventional drugs in the treatment of the patients with hypertension and type 2 diabetes can improve the total effective rate of treatment,improve the levels of blood glucose,blood lipid indexes and arteriosclerosis indexes,and reduce the levels of vascular endothelial function indexes.Moreover,it is superior to single conventional drug therapy.
NETL
NSTL
万方数据
维普
