Effects of invasive-noninvasive sequential mechanical ventilation in treatment of patients with chronic obstructive pulmonary disease complicated with respiratory failure
Objective:To investigate effects of invasive-noninvasive sequential mechanical ventilation in treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods:The clinical data of 66 patients with COPD complicated with respiratory failure admitted to this hospital from June 2022 to June 2023 were retrospectively analyzed.According to the different methods of mechanical ventilation,they were divided into observation group and control group,33 cases in each group.The control group was treated with invasive mechanical ventilation,while the observation group was treated with invasive-noninvasive sequential mechanical ventilation.The total mechanical ventilation time,the invasive mechanical ventilation time,the hospitalization time,the levels of arterial blood gas indexes[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),pH value]and cardiac function injury indexes[creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI)]before and after treatment,the offline success rate within 2 weeks of treatment,and the incidence of complications were compared between the two groups.Results:After the treatment,the total mechanical ventilation time,the invasive mechanical ventilation time and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PaO2 level and pH value of the observation group were higher than those of the control group,the PaCO2 level was lower than that of the control group,and the differences were statistically significant(P<0.05).Further,the offline success rate in the observation group was 96.97%(32/33),which was higher than 75.76%(25/33)in the control group;the incidence of complications was 6.06%(2/33),which was lower than 24.24%(8/33)of the control group;and the differences were statistically significant(P<0.05).Conclusions:Invasive-noninvasive sequential mechanical ventilation for the patients with COPD complicated with respiratory failure can shorten the mechanical ventilation time and the hospitalization time,improve the blood gas index levels and the cardiac function,improve the offline success rate,and reduce the incidence of complications.Moreover,it is superior to conventional invasive mechanical ventilation.
NETL
NSTL
万方数据
维普
