Effects of Moxifloxacin combined with Capreomycin in treatment of multi-drug resistant pulmonary tuberculosis
Objective:To observe effects of Moxifloxacin combined with Capreomycin in treatment of patients with multidrug-resistant pulmonary tuberculosis.Methods:A prospective study was conducted on 150 patients with multi-drug resistant pulmonary tuberculosis admitted to this hospital from March 2021 to January 2023.They were divided into study group and control group according to the random number table method,75 cases in each.Both groups were given routine treatment.On this basis,the control group was treated with Capreomycin,while the study group was treated with Moxifloxacin on the basis of that of the control group.Both groups were treated for 8 weeks.The clinical efficacy,the levels of inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),interferon-γ(IFN-γ),white blood cell count(WBC)],lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC],and serological indexes[adenosine deaminase(ADA),chemokine receptor 4(CXCR4)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.00%(69/75),which was higher than 80.00%(60/75)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CRP,PCT and WBC in the study group were lower than those in the control group,the level of IFN-γ was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and FEV1/FVC in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CXCR4 and ADA in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Moxifloxacin combined with Capreomycin in the treatment of the multi-drug resistant pulmonary tuberculosis patients can improve the total effective rate of treatment and the levels of lung function indexes,regulate the levels of inflammatory indicators,and reduce the levels of serological indexes.Moreover,it is superior to single Capreomycin treatment.
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NSTL
万方数据
维普
