Application effects of caudal combined intermediate approach in laparoscopic complete mesocolic excision for colon cancer patients
Objective:To observe application effects of caudal combined intermediate approach in laparoscopic complete mesocolic excision for colon cancer patients.Methods:The clinical data of 60 patients with right colon cancer and incomplete intestinal obstruction admitted to this hospital from January 2020 to December 2021 were retrospectively analyzed.According to the different surgical approaches,they were divided into control group and study group,30 cases in each group.Both groups were treated with laparoscopic complete mesocolic excision for colon cancer.The control group was treated with the cranial combined intermediate approach,while the study group was treated with the caudal combined intermediate approach.Both groups were followed up for 1 year.The levels of operation-related indicators(operation time,intraoperative blood loss,defecation time,exhaust time,postoperative hospitalization time),stress indicators[adrenocorticotropic hormone(ACTH),cortisol(Cor),norepinephrine(NE),epinephrine(E)],inflammatory indicators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)],tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9)]before and after the surgery,the incidence of complications,and the 1-year survival rate were compared between the two groups.Results:The operation time,the defecation time,the exhaust time and the postoperative hospitalization time of the study group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the differences were statistically significant(P<0.05).One day after the surgery,the levels of ACTH,Cor,NE,E,CRP,TNF-α and IL-6 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Three days after the surgery,the levels of CEA,CA125 and CA19-9 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there were no significant differences in the incidence of complications and the 1-year survival rate between the two groups(P>0.05).Conclusions:The caudal combined intermediate approach in the patients with laparoscopic complete mesocolic excision of colon cancer can improve the levels of operation-related indicators and reduce the levels of postoperative stress indicators,inflammatory indicators and tumor markers.Moreover,it is superior to the cranial combined intermediate approach.
NETL
NSTL
万方数据
维普
