Application effects of Dezocine combined with Propofol anesthesia in patients undergoing radical gastrectomy
Objective:To observe application effects of Dezocine combined with Propofol anesthesia in patients undergoing radical gastrectomy.Methods:A prospective study was conducted on 92 patients undergoing radical gastrectomy admitted to the hospital from May 2019 to May 2022.According to the random number table method,they were divided into control group and observation group,46 cases in each group.The control group was anesthetized with Fentanyl combined with Propofol,while the observation group was anesthetized with Dezocine combined with Propofol.The levels of hemodynamic indexes[mean arterial pressure(MAP),heart rate]and stress response indexes(cortisol,adrenocorticotropic hormone)at different time[before anesthesia induction(T0),0.5 h after the surgery(T1),end of the surgery(T2)],the cognitive function[mini-mental state examination(MMSE)],and the incidence of adverse reactions were compared between the two groups.Results:At T0,T1 and T2,the MAP and heart rate of the two groups decreased and then increased.At T0 and T2,there were no statistically significant differences in MAP and heart rate levels between the two groups(P>0.05).At T1,the heart rate and MAP level of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).24 h after the surgery,the levels of cortisol and adrenocorticotropic hormone in the two groups were higher than those before operation,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).24 h after the surgery,the MMSE scores of the two groups were lower than those before the surgery,but that in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Dezocine combined with Propofol anesthesia can improve the cognitive function scores and the hemodynamic index levels of the patients undergoing radical gastrectomy,and reduce the levels of stress response indexes and the incidence of adverse reactions.Moreover,it is superior to Fentanyl combined with Propofol anesthesia.
NETL
NSTL
万方数据
维普
