Effects of Guanxin Shutong capsules combined with Isosorbide mononitrate on prevention of reperfusion arrhythmia after PCI in patients with acute myocardial infarction
Objective:To observe effects of Guanxin Shutong capsules combined with Isosorbide mononitrate on prevention of reperfusion arrhythmia(RA)after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods:A prospective study was conducted on 86 patients with AMI who underwent PCI in this hospital from September 2020 to September 2022.According to the random number table method,they were divided into control group and study group,43 cases in each group.The control group was treated with Isosorbide mononitrate tablets,while the study group was treated with Guanxin Shutong capsules on the basis of that of the control group.The levels of myocardial injury markers[creatine kinase isoenzyme(CK-MB),N-terminal pro-brain natriuretic peptide(NT-proBNP),troponin I(cTnI)]and inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),galectin-3(Gal-3)],the incidence of RA,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of CK-MB,NT-proBNP and cTnI in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,hs-CRP and Gal-3 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of RA in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Guanxin Shutong capsules combined with Isosorbide mononitrate can reduce the levels of myocardial injury markers and inflammatory factors and the incidence of RA in the patients with AMI after PCI.Moreover,it is superior to single Isosorbide mononitrate tablets treatment.
NETL
NSTL
万方数据
维普
