Correlations among serum hs-CRP,apoA1/apoB,UA levels and number of arterial branches with lesions and degree of stenosis in patients with acute myocardial infarction combined with type 2 diabetes mellitus
Objective:To explore correlations among serum high-sensitivity C-reactive protein(hs-CRP),apolipoprotein A1/apolipoprotein B(apoA1/apoB),uric acid(UA)levels and number of arterial branches with lesions and degree of stenosis in patients with acute myocardial infarction(AMI)combined with type 2 diabetes mellitus(T2DM).Methods:A prospective study was conducted on 150 patients with AMI admitted to the hospital from May 2021 to May 2023,and they were set as the study group.According to whether they were combined with T2DM,they were divided into combined group(n=100)and uncombined group(n=50).Another 50 healthy subjects in the same period were selected as the control group.The levels of serum hs-CRP,apoA1/apoB and UA in the three groups,in the patients with different Gensini scores in the combined group,and in the patients with different numbers of arterial branches with lesions in the combined group were compared.Spearman correlation analysis was used to analyze the correlations among the serum hs-CRP,apoA1/apoB,UA levels and the number of arterial branches with lesions and the degree of stenosis in the patients with AMI and T2DM.Results:The levels of hs-CRP and UA in the combined group were higher than those in the uncombined group and the control group,and those in the uncombined group were higher than those in the control group;the apoA1/apoB in the combined group was lower than that in the uncombined group and the control group,and that in the uncombined group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of hs-CRP and UA in the patients with Gensini score>40 were lower than those in the patients with Gensini score of 21-40 points and 0-20 points,and those in the patients with Gensini score of 21-40 points were lower than those in patients with Gensini score of 0-20 points;the apoA1/apoB in the patients with Gensini score>40 was lower than those in the patients with Gensini score of 21-40 points and 0-20 points,and that in the patients with Gensini score of 21-40 points was lower than that in patients with Gensini score of 0-20 points;and the differences were statistically significant(P<0.05).The levels of hs-CRP and UA in the patients with 3 branches with lesions were higher than those in the patients with 1 and 2 branches with lesions,and those in the patients with 2 branches with lesions were higher than those in patients with 1 branch with lesion;the apoA1/apoB in the patients with 3 branches with lesions was lower than those in the patients with 1 and 2 branches with lesions,and that in the patients with 2 branches with lesions was lower than that in patients with 1 branch with lesion;and the differences were statistically significant(P<0.05).The serum hs-CRP and UA levels in the combined group were positively correlated with the number of arterial branches with lesions and the Gensini score(r>0,P<0.05),while the apoA1/apoB ratio was negatively correlated with the number of arterial branches with lesions and the Gensini score(r<0,P<0.05).Conclusions:The levels of serum hs-CRP and UA are positively correlated with the number of the number of arterial branches with lesions and the Gensini score in the patients with AMI combine with T2DM,while the serum apoA1/apoB is negatively correlated with the number of arterial branches with lesions and the Gensini score.
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