Correlations among serum inflammatory factors,vitamin B12,ferritin levels and insulin resistance in patients with gestational diabetes mellitus
Objective:To observe correlations among serum inflammatory factors[procalcitonin(PCT),C-reactive protein(CRP)],vitamin B12,ferritin levels and insulin resistance in patients with gestational diabetes mellitus(GDM).Methods:A cross-sectional study was conducted on 102 pregnant women diagnosed with GDM in the hospital from March 2021 to March 2023,and they were set as the observation group.A cross-sectional study was conducted on 102 healthy pregnant women who were examined in the hospital during the same period,and they were set as the control group 1.A cross-sectional study was conducted on 102 healthy non-pregnant women who underwent physical examination in the hospital during the same period,and they were set as control group 2.The fasting insulin(FINS),fasting blood glucose,insulin resistance index(HOMA-IR),serum ferritin,vitamin B12,PCT and CRP levels were compared among the three groups.The levels of serum ferritin,vitamin B12,PCT and CRP in the GDM patients with or without insulin resistance were compared.Pearson correlation analysis was used to analyze the correlations among the serum ferritin,vitamin B12,PCT,CRP levels and HOMA-IR in the GDM patients.Results:The levels of FINS,fasting blood glucose,HOMA-IR,serum ferritin,PCT and CRP in the observation group were higher than those in the control group 1 and the control group 2,and those in the control group 1 were higher than those in the control group 2;the level of vitamin B12 in the observation group was lower than that in the control group 1 and the control group 2,and that in the control group 1 was lower than that in the control group 2;and the differences were statistically significant(P<0.05).The levels of serum ferritin,PCT and CRP in the GDM patients with insulin resistance were higher than those in the GDM patients without insulin resistance,the level of vitamin B12 was lower than that in the GDM patients without insulin resistance,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum ferritin,CRP and PCT levels in the GDM patients were positively correlated with the HOMA-IR level(r>0,P<0.05),and the vitamin B12 in the GDM patients was negatively correlated with the HOMA-IR level(r<0,P<0.05).Conclusions:The serum ferritin,CRP and PCT levels in the GDM patients are positively correlated with the HOMA-IR level,and the vitamin B12 in the GDM patients was negatively correlated with the HOMA-IR level.
NETL
NSTL
万方数据
维普
