左乙拉西坦与丙戊酸钠治疗癫痫患儿的效果比较
Comparison of effects of Levetiracetam and Sodium valproate in treatment of children with epilepsy
王东勤 1张高利 2刘雪玲3
作者信息
- 1. 上蔡重阳医院,儿科,河南 驻马店 463800
- 2. 上蔡重阳医院,内科,河南 驻马店 463800
- 3. 上蔡县中医院儿科,河南 驻马店 463800
- 折叠
摘要
目的:比较左乙拉西坦与丙戊酸钠治疗癫痫患儿的效果.方法:选取 2020 年 2 月至 2023 年 2 月上蔡重阳医院儿科收治的 80 例癫痫患儿进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各 40 例.对照组口服丙戊酸钠片治疗,观察组口服左乙拉西坦片治疗.比较两组临床疗效,治疗前后癫痫发作频率、发作持续时间、脑损伤指标[胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)和胰岛素样生长因子 1(IGF-1)]水平、生命质量[儿童生活质量普通适用核心量表 4.0(PedsQL4.0)]评分,以及不良反应发生率.结果:观察组治疗总有效率为 90.00%(36/40),高于对照组的 72.50%(29/40),差异有统计学意义(P<0.05);治疗后,观察组癫痫发作频率及血清IGF-1、GFAP和NSE水平均低于对照组,PedsQL4.0 评分高于对照组,癫痫发作持续时间短于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为 10.00%(4/40),低于对照组的 32.50%(13/40),差异有统计学意义(P<0.05).结论:左乙拉西坦治疗小儿癫痫的效果显著,能够有效降低患儿癫痫发作频率,缩短癫痫发作持续时间,减轻神经损伤,改善生命质量,还能降低不良反应发生率,效果及安全性均优于丙戊酸钠.
Abstract
Objective:To compare effects of Levetiracetam and Sodium valproate in treatment of children with epilepsy.Methods:A prospective study was conducted on 80 children with epilepsy admitted to the department of pediatrics of Shangcai Chongyang Hospital from February 2020 to February 2023.According to the random number table method,they were divided into observation group and control group,40 cases in each group.The control group was treated with Sodium valproate tablets orally,while the observation group was treated with Levetiracetam tablets orally.The clinical efficacy,the seizure frequency,the seizure duration,the brain injury indexes[glial fibrillary acidic protein(GFAP),neuron specific enolase(NSE)and insulin-like growth factor 1(IGF-1)]levels,the quality of life[the pediaric quality of life inventory measurement methods 4.0(PedsQL4.0)]score before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.00%(36/40),which was higher than 72.50%(29/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the seizure frequency,the serum IGF-1,GFAP and NSE levels in the observation group were lower than those in the control group,the PedsQL4.0 score was higher than that in the control group,and the seizure duration was shorter than that in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 10.00%(4/40),which was lower than 32.50%(13/40)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Levetiracetam is effective in the treatment of epilepsy in the children.It can effectively reduce the of seizure frequency,shorten the seizure duration,reduce the nerve damage,improve the quality of life,and reduce the incidence of adverse reactions.Moreover,it is superior to Sodium valproate treatment.
关键词
儿童/癫痫/丙戊酸钠/左乙拉西坦/胰岛素样生长因子1/神经元特异性烯醇化酶/胶质纤维酸性蛋白Key words
Children/Epilepsy/Sodium valproate/Levetiracetam/Insulin-like growth factor 1/Neuron specific enolase/Glial fibrillary acidic protein引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据