Analysis of pathogen distribution and drug resistance in children with recurrent upper respiratory tract infection
Objective:To analyze pathogen distribution and drug resistance in children with recurrent upper respiratory tract infection.Methods:A cross-sectional study was conducted on 120 children with recurrent upper respiratory tract infection admitted to the hospital from January 2022 to January 2023.The bacterial pathogen culture and the drug sensitivity test were performed.The distribution of pathogenic bacteria in these children was statistically analyzed.The drug resistance of main gram-negative and positive bacteria was analyzed.Results:161 strains of pathogenic bacteria were detected in the 120 children,including 114 strains of Gram-negative bacteria,accounting for 70.81%,Klebsiella pneumoniae is the main gram-negative pathogen(29.81%);there were 47 strains of gram-positive bacteria,accounting for 29.19%,of which Staphylococcus aureus is the main gram positive pathogen(19.25%).Klebsiella pneumoniae had the highest resistance to Ampicillin(100.00%),and had low resistance to compound Sulfamethoxazole,Cefazolin,Ceftriaxone,Ampicillin/Sulbactam,Gentamicin,Ceftazidime,and Tobramycin(all<20.00%);and it was not resistant to Ciprofloxacin,Levofloxacin,Amikacin,Ertapenem,Piperacillin/Tazobactam,Cefepime,Cefotetan,and Imipenem(all 0).Escherichia coli had the highest resistance to Ampicillin(82.93%),had higher resistance to compound Sulfamethoxazole,Cefazolin,Ceftriaxone,Ampicillin/Sulbactam,Gentamicin,Ciprofloxacin and Levofloxacin,and had lower resistance to Tobramycin and Amikacin(all<10.00%);and it was not resistant to Piperacillin/Tazobactam,Cefepime,Cefotetan,Imipenem and Ertapenem(all 0).Staphylococcus aureus had the highest resistance to Oxacillin and Erythromycin,both of which were 70.97%;had higher resistance to Amoxicillin,Tetracycline,Clindamycin,compound Sulfamethoxazole,Rifampicin,Levofloxacin,Ampicillin,Chloramphenicol,Gentamicin,Penicillin,Cefuroxime and Cephalothin;and had lower resistance to Imipenem and Cefotaxime and no resistance to Vancomycin(0).Conclusions:The main pathogenic bacteria in the children with recurrent upper respiratory tract infection are Gram-negative Klebsiella pneumoniae and Gram-positive Staphylococcus aureus.The resistance of Klebsiella pneumoniae to Ampicillin is 100.00%,and the resistance of Staphylococcus aureus to Oxacillin and Erythromycin is 70.97%.Therefore,antibiotic treatment should be reasonably selected in the clinical practice.
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