Application effects of Ticagrelor combined with Aspirin in patients with coronary heart disease undergoing interventional therapy
Objective:To observe application effects of Ticagrelor combined with Aspirin in patients with coronary heart disease undergoing interventional therapy.Methods:A prospective study was conducted on 100 patients with coronary heart disease admitted to the hospital from January 2019 to December 2020.They were divided into control group and observation group by using the random number table method,50 cases in each group.Both groups were treated with percutaneous coronary intervention(PCI).The control group was treated with Clopidogrel combined with Aspirin,while the observation group was treated with Ticagrelor combined with Aspirin.The clinical efficacy,the levels of cardiac function indexes[cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF)],hemorheology indexes and oxidative stress indexes[lipid peroxide(LPO),superoxide dismutase(SOD),malondialdehyde(MDA)]before and after the treatment,and incidence of major adverse cardiovascular events(MACE)during 3 months of follow-up were compared between the two groups.Results:The total effective rate of the observation group was 98.00%(49/50),which was higher than 84.00%(42/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CO,SV and LVEF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the whole blood low shear viscosity,whole blood high shear viscosity and plasma viscosity in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of MDA and LPO in the observation group were lower than those in the control group,the level of SOD was higher than that in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of MACE in the observation group was 6.12%(3/49),which was lower than 20.83%(10/48)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Ticagrelor combined with Aspirin in the patients with coronary heart disease undergoing interventional therapy can improve the total effective rate of treatment and the levels of cardiac function indexes,improve the levels of oxidative stress indexes,and reduce the levels of hemorheology indexes and the incidence of MACE.Moreover,it is superior to Clopidogrel combined with Aspirin treatment.
AspirinTicagrelorPercutaneous coronary interventionCoronary heart diseaseOxidative stressHemorheologyCardiac function
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