Effects of Dapagliflozin combined with conventional drugs in treatment of patients with chronic heart failure
Objective:To observe effects of Dapagliflozin combined with conventional drugs in treatment of patients with chronic heart failure(CHF).Methods:A prospective study was conducted on 92 patients with CHF admitted to the hospital from June 2020 to December 2022.According to the random number table method,they were divided into control group and observation group,46 cases in each group.The control group was given conventional drug treatment,while the observation group was treated with Dapagliflozin on the basis of that of the control group.The clinical efficacy,the levels of cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV)]and myocardial injury markers[cardiac troponin I(cTnI),cardiac troponin T(cTnT),N-terminal pro-brain natriuretic peptide(NT-proBNP)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.83%(45/46),which was higher than 78.26%(36/46)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the LVEF levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of LVEDV and LVESV in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of cTnI,cTnT and NT-proBNP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dapagliflozin combined with conventional drugs in the treatment of the CHF patients can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of myocardial injury markers.Moreover,it is superior to single conventional drug treatment.
万方数据
维普
