Effects of Ulinastatin combined with sequential mechanical ventilation in treatment of patients with acute respiratory distress syndrome
Objective:To investigate effects of Ulinastatin combined with sequential mechanical ventilation in treatment of patients with acute respiratory distress syndrome(ARDS).Methods:The clinical data of 106 patients with ARDS admitted to this hospital from January 2021 to April 2023 were retrospectively analyzed.According to different treatment options,they were divided into study group and control group,53 cases in each group.The control group was treated with invasive-noninvasive sequential mechanical ventilation,while the study group was treated with Ulinastatin on the basis of that of the control group.The levels of pulmonary compliance,blood gas indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),oxygenation index(OI)],inflammatory indexes[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After 7 days of treatment,the dynamic and static lung compliance of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).After 7 days of treatment,the level of PaCO2 in the study group was lower than that in the control group,the levels of PaO2 and OI were higher than those in the control group,and the differences were statistically significant(P<0.05).After 7 days of treatment,the levels of IL-6,IL-1β and TNF-α in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,within 7 days of treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ulinastatin combined with sequential mechanical ventilation in the treatment of the ARDS patients can improve the pulmonary compliance,improve the blood gas index levels,and reduce the inflammatory index levels.Moreover,it is superior to single sequential mechanical ventilation treatment.
万方数据
维普
