Effects of Budesonide and Formoterol combined with noninvasive positive pressure ventilation in treatment of elderly patients with chronic obstructive pulmonary disease complicated with respiratory failure
Objective:To observe effects of Budesonide and Formoterol combined with noninvasive positive pressure ventilation in treatment of elderly patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods:A prospective study was conducted on 100 elderly patients with COPD and respiratory failure admitted to this hospital from January 2022 to January 2023.According to the random number table method,they were divided into observation group and control group,50 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with non invasive positive pressure ventilation,while the observation group was treated with Budesonide and Formoterol on the basis of that of the control group.The clinical efficacy,the blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),oxygenation index(OI)]levels,the lung function indexes[respiratory rate,forced vital capacity(FVC),peak expiratory flow(PEF)]levels,the inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),interleukin-33(IL-33)]levels,the incidence of adverse reactions,and the readmission rate were compared between the two groups.Results:The total effective rate of the observation group was 94.00%(47/50),which was higher than 78.00%(39/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PaO2,OI,FVC and PEF in the observation group were higher than those in the control group,the levels of PaCO2 and respiratory rate were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6 and IL-33 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The readmission rate of the observation group was 4.00%(2/50),which was lower than 16.00%(8/50)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Budesonide and Formoterol combined with non invasive positive pressure ventilation in the treatment of the elderly patients with COPD complicated with respiratory failure can improve the total effective rate of treatment,improve the levels of blood gas analysis indexes and lung function indexes,and reduce the levels of inflammatory factors and the readmission rate.Moreover,it is superior to single noninvasive positive pressure ventilation treatment.
ElderlyChronic obstructive pulmonary diseaseRespiratory failureNoninvasive positive pressure ventilationBudesonide and FormoterolBlood gas analysisLung function
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