Effects of Oryz-Aspergillus enzyme and pancreatin tablets combined with Rabeprazole and Mosapride in treatment of patients with reflux esophagitis
Objective:To investigate effects of Oryz-Aspergillus enzyme and pancreatin tablets combined with Rabeprazole and Mosapride in treatment of patients with reflux esophagitis.Methods:A prospective study was conducted on 74 patients with reflux esophagitis admitted to this hospital from May 2022 to May 2023.According to the random number table method,they were divided into control group and observation group,37 cases in each group.The control group was treated with Rabeprazole combined with Mosapride,while the observation group was treated with Oryz-Aspergillus enzyme and pancreatin tablets on the basis of that of the control group.The clinical efficacy,the clinical symptom scores,the serum inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.89%(34/37),which was higher than 72.97%(27/37)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of clinical symptoms such as heartburn,acid reflux,belching,sternal pain,loss of appetite and the levels of serum hs-CRP,TNF-α and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Aspergillus oryzae pancreatin tablets combined with Rabeprazole and Mosapride in the treatment of the patients with reflux esophagitis can significantly improve the total effective rate of treatment,accelerate the relief of clinical symptoms,and reduce the levels of serum inflammatory factors.Moreover,it is superior to single Rabeprazole and Mosapride treatment.
Oryz-Aspergillus enzyme and pancreatin tabletsReflux esophagitisRabeprazoleMosaprideInflammatory factor
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