Effects of Esmolol combined with Norepinephrine and fluid resuscitation in treatment of patients with septic shock
Objective:To observe effects of Esmolol combined with Norepinephrine and fluid resuscitation in treatment of patients with septic shock.Methods:The clinical data of 88 patients with septic shock admitted to this hospital from January 2020 to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,44 cases in each group.The control group was treated with Norepinephrine combined with fluid resuscitation,while the study group was treated with Esmolol on the basis of that of the control group.The levels of hemodynamic indexes[mean arterial pressure(MAP),heart rate]and tissue oxygenation indexes[central venous pressure(CVP)oxygenation index(PaO2/FiO2),blood lactic acid],the clinical efficacy,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the MAP levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the heart rate levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of CVP and PaO2/FiO2 index in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of blood lactic acid in the two groups were lower than those before the treatment,and that in the study group were lower than that in the control group;and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 95.45%(42/44),which was higher than 79.55%(35/44)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Esmolol combined with Norepinephrine and fluid resuscitation in the treatment of the patients with septic shock can improve the total effective rate of treatment and improve the levels of hemodynamic indexes and tissue oxygenation indexes.Moreover,it is superior to Norepinephrine combined with fluid resuscitation.
万方数据
维普
