Effects of Methylprednisolone combined with Azithromycin in treatment of children with mycoplasma infectious lobar pneumonia
Objective:To investigate effects of Methylprednisolone combined with Azithromycin in treatment of children with mycoplasma infectious lobar pneumonia.Methods:A prospective study was conducted on 82 children with mycoplasma infectious lobar pneumonia admitted to this hospital from March 2021 to March 2023.According to the random number table method,they were randomly divided into control group and study group,41 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with Methylprednisolone on the basis of that of the control group.The clinical efficacy,the symptom disappearance time,the hospitalization time,the serum inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.68%(38/41),which was higher than 75.61%(31/41)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,chest tightness,cough,lung shadow and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum IL-6,CRP and TNF-α in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Methylprednisolone combined with Azithromycin in the treatment of the children with mycoplasma infectious lobar pneumonia can improve the clinical efficacy,reduce the levels of inflammatory factors,accelerate the relief of symptoms and shorten the hospitalization time.Moreover,it is superior to single Azithromycin treatment.
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