Effects of Caffeine citrate combined with nasal continuous positive airway pressure ventilation in treatment of premature infants with respiratory distress syndrome
Objective:To observe effects of Caffeine citrate combined with nasal continuous positive airway pressure ventilation in treatment of premature infants with respiratory distress syndrome.Methods:A prospective study was conducted on 106 premature infants with respiratory distress syndrome admitted to the hospital from May 2021 to August 2022.According to the random number table method,they were divided into study group and control group,53 cases in each group.The control group was treated with nasal continuous positive airway pressure ventilation,while the study group was treated with Caffeine citrate injection on the basis of that of the control group.The total effective rate,the blood gas index[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2)]levels,the Bayley scales of infant and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 96.23%,which was significantly higher than 84.91%of the control group,and the difference was statistically significant(P<0.05).After 7 days of treatment,the PaO2 levels of the two groups were higher than those before treatment,and that in the study group was higher than that in the control group;the PaCO2 level of the two groups was lower than that before treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Caffeine citrate combined with nasal continuous positive airway pressure ventilation in the treatment of the premature infants with respiratory distress syndrome can improve the total effective rate and improve the levels of blood gas analysis indexes.Moreover,it is superior to single nasal continuous positive airway pressure ventilation treatment.
万方数据
维普
