Effects of Shuxuening injection combined with Metoprolol in treatment of elderly patients with coronary heart disease and angina pectoris
Objective:To observe effects of Shuxuening injection combined with Metoprolol in treatment of elderly patients with coronary heart disease and angina pectoris.Methods:A prospective study was conducted on 78 elderly patients with coronary heart disease and angina pectoris admitted to this hospital from June 2021 to June 2023.According to the random number table method,they were divided into control group and observation group,39 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with Metoprolol,while the observation group was treated with Shuxuening injection on the basis of that of the control group.Both groups were treated for 3 weeks.The clinical efficacy,the frequency and duration of angina pectoris attacks,the pain[visual analogue scale(VAS)]score,the vascular endothelial function indexes[nitric oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),thromboxane B2(TXB2)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.31%(36/39),which was higher than 74.36%(29/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the frequency of angina pectoris attacks in the observation group was less than that in the control group,the duration of the attack was shorter than that in the control group,the VAS score was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NO and VEGF in the observation group were higher than those in the control group,the levels of ET-1 and TXB2 were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Shuxuening injection combined with Metoprolol in the treatment of the elderly patients with coronary heart disease and angina pectoris can improve the total effective rate of treatment,reduce the frequency of angina pectoris attacks and the VAS scores,shorten the duration of attacks,and improve the levels of vascular endothelial function indexes.Moreover,it is superior to single Metoprolol treatment.
万方数据
维普
