Efficiency of combined detection of liver blood flow ultrasound parameters,serum IGFBP-3 and miR-9a-5p levels in diagnosis of rebleeding in patients with liver cirrhosis and gastric fundus variceal bleeding
Objective:To analyze efficiency of combined detection of liver blood flow ultrasound parameters,serum insulin-like growth factor binding protein-3(IGFBP-3)and microRNA-9a-5p(miR-9a-5p)levels in diagnosis of rebleeding in patients with liver cirrhosis and esophagogastric variceal bleeding(EGVB).Methods:A cross-sectional study was conducted on 124 liver cirrhosis patients with EGVB admitted to the hospital from October 2018 to March 2022.According to whether rebleeding occurred within 6 months after the treatment,they were divided into bleeding group(70 cases)and non-bleeding group(54 cases).The levels of liver blood flow ultrasound parameters[portal vein diameter(PVD),hepatic vein damping index(HV-DI),portal vein blood flow velocity(PVV)],the serum IGFBP-3 level and the miR-9a-5p level were compared between the two groups.The receiver operating characteristic curve(ROC)was drawn to analyze the efficiency of combined detection of liver blood flow ultrasound parameters,serum IGFBP-3 and miR-9a-5p levels in the diagnosis of rebleeding in patients with liver cirrhosis and EGVB.Results:1 month after the treatment,the levels of PVD,HV-DI and serum IGFBP-3,miR-9a-5p in the two groups were lower than those before the treatment,but those in the bleeding group were higher than those in the non-bleeding group;the PVV levels of the two groups were higher than those before the treatment,but that in the bleeding group was lower than that in the non-bleeding group,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of PVD,HV-DI,PVV,IGFBP-3 and miR-9a-5p levels in the diagnosis of rebleeding in patients with liver cirrhosis and EGVB 1 month after the treatment were 0.760,0.761,0.764,0.753,0.780 and 0.930,respectively,and the efficiency of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of liver blood flow ultrasound parameters,serum IGFBP-3 and miR-9a-5p levels in the diagnosis of rebleeding in the patients with liver cirrhosis and EGVB is higher than that of single detection of the five.
万方数据
维普
