Effects of Argatroban combined with Aspirin and Clopidogrel in treatment of patients with acute cerebral infarction
Objective:To observe effects of Argatroban combined with Aspirin and Clopidogrel in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 68 patients with acute cerebral infarction admitted to this hospital from January 2022 to January 2023.According to the random number table method,they were divided into study group and control group,34 cases in each group.The control group was treated with Aspirin combined with Clopidogrel,while the study group was treated with Argatroban on the basis of those of the control group.The clinical efficacy,the limb motor function[Fugl-Meyer motor assessment(FMA)]score,the daily activity ability[Barthel index(BI)]score,the neurological deficit degree[National Institutes of Health stroke scale(NIHSS)]score,the platelet index[aggregation rate,adhesion rate]levels,the cerebral hemodynamic index[anterior cerebral artery(ACA),basilar artery(BA)blood flow velocity]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 88.24%(30/34),which was higher than 67.65%(23/34)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the FMA and BI scores of the two groups were higher than those before the treatment,that in the study group was higher than that in the control group,and the differences were statistically significant(P<0.05).The NIHSS scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).The platelet aggregation rate and the adhesion rate of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The blood flow velocities of ACA and BA in the two groups was higher than those before the treatment,that in the study group was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Argatroban combined with Aspirin and Clopidogrel in the treatment of the patients with acute cerebral infarction can improve the total effective rate of treatment,the limb motor function scores,the daily living ability scores and the cerebral hemodynamics index levels,and reduce the neurological deficit degree score and the platelet index levels.Moreover,it is superior to Aspirin combined with Clopidogrel treatment.
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